The large-scale solid-phase synthesis of long-chain polypeptides (usually polypeptides with more than 50 amino acids) faces many technical bottlenecks, including low synthesis efficiency, many side reactions, difficult purity control, and high cost.
Reverse phase chromatography (RPC), as an efficient separation technology based on the principle of hydrophobic interaction, realizes the separation of peptides and proteins by virtue of the specific interaction between the stationary phase and the mobile phase. At present, peptide reverse phase purification technology is widely used in drug research and development, biological activity research and other fields, and has become the "gold standard" of peptide purification.
The production of polypeptides is generally divided into chemical synthesis and biosynthesis. Whether chemical synthesis or biosynthesis, the production of polypeptides requires strict control of reaction conditions, purification steps and quality detection to ensure the purity and quality of polypeptides.
In 2023, the Nobel Prize in chemistry was announced, and moungi g. bawendi, Louis E. brus, Alexei I. ekimov won the prize
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